8C3U

Crystal Structure of human IL-1beta in complex with a low molecular weight antagonist

8C3U の概要

• エントリーDOI: 10.2210/pdb8c3u/pdb
• 分子名称: Interleukin-1 beta, (S)-4'-hydroxy-3'-(6-methyl-2-oxo-3-(1H-pyrazol-4-yl)indolin-3-yl)-[1,1'-biphenyl]-2,4-dicarboxylic acid (3 entities in total)
• 機能のキーワード: beta trefoil fold; secreted, cytokine
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35730.56

構造登録者

Rondeau, J.-M.,Lehmann, S.,Koch, E. (登録日: 2022-12-28, 公開日: 2023-09-13, 最終更新日: 2024-03-27)

• 主引用文献: Hommel, U.,Hurth, K.,Rondeau, J.M.,Vulpetti, A.,Ostermeier, D.,Boettcher, A.,Brady, J.P.,Hediger, M.,Lehmann, S.,Koch, E.,Blechschmidt, A.,Yamamoto, R.,Tundo Dottorello, V.,Haenni-Holzinger, S.,Kaiser, C.,Lehr, P.,Lingel, A.,Mureddu, L.,Schleberger, C.,Blank, J.,Ramage, P.,Freuler, F.,Eder, J.,Bornancin, F.; Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1 beta.; Nat Commun, 14:5497-5497, 2023; PubMed: 37679328; DOI: 10.1038/s41467-023-41190-0

実験手法

X-RAY DIFFRACTION (1.945 Å)