8C12

Identification of an intermediate activation state of PAK5 reveals a novel mechanism of kinase inhibition.

This is a non-PDB format compatible entry.

Summary for 8C12

• Entry DOI: 10.2210/pdb8c12/pdb
• Descriptor: Serine/threonine-protein kinase PAK 5, PAK5-Af17 (3 entities in total)
• Functional Keywords: kinase, pak5, affimer, urothelial cancer., transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 46055.12

Authors

Martin, H.L.,Turner, A.L.,Trinh, C.H.,Bayliss, R.W.,Tomlinson, D.C. (deposition date: 2022-12-19, release date: 2023-10-25)

• Primary citation: Martin, H.L.,Turner, A.L.,Higgins, J.,Tang, A.A.,Tiede, C.,Taylor, T.,Siripanthong, S.,Adams, T.L.,Manfield, I.W.,Bell, S.M.,Morrison, E.E.,Bond, J.,Trinh, C.H.,Hurst, C.D.,Knowles, M.A.,Bayliss, R.W.,Tomlinson, D.C.; Affimer-mediated locking of p21-activated kinase 5 in an intermediate activation state results in kinase inhibition.; Cell Rep, 42:113184-113184, 2023; PubMed: 37776520; DOI: 10.1016/j.celrep.2023.113184

Experimental method

X-RAY DIFFRACTION (1.549 Å)