8BSU

Crystal structure of the kainate receptor GluK3-H523A ligand binding domain in complex with kainate and the positive allosteric modulator BPAM344 at 2.9A resolution

8BSU の概要

• エントリーDOI: 10.2210/pdb8bsu/pdb
• 分子名称: Glutamate receptor ionotropic, kainate 3, 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, ZINC ION, ... (9 entities in total)
• 機能のキーワード: ionotropic glutamate receptor, gluk3 ligand-binding domain, membrane protein, gluk3-h523a-lbd, positive allosteric modulator, bpam344
• 由来する生物種: Rattus norvegicus (Norway rat); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 240078.07

構造登録者

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (登録日: 2022-11-26, 公開日: 2023-12-13, 最終更新日: 2024-07-03)

• 主引用文献: Bay, Y.,Venskutonyte, R.,Frantsen, S.M.,Thorsen, T.S.,Musgaard, M.,Frydenvang, K.,Francotte, P.,Pirotte, B.,Biggin, P.C.,Kristensen, A.S.,Boesen, T.,Pickering, D.S.,Gajhede, M.,Kastrup, J.S.; Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.; Febs J., 291:1506-1529, 2024; PubMed: 38145505; DOI: 10.1111/febs.17046

実験手法

X-RAY DIFFRACTION (2.9 Å)