8BRC

Crystal structure of the adduct between human serum transferrin and cisplatin

Summary for 8BRC

Entry DOI	10.2210/pdb8brc/pdb
Descriptor	Serotransferrin, FE (III) ION, MALONATE ION, ... (7 entities in total)
Functional Keywords	human serum transferrin, serotransferrin, iron binding transport protein, cisplatin, metal binding, metallodrug, metal transport
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	75906.74
Authors	Troisi, R.,Galardo, F.,Ferraro, G.,Sica, F.,Merlino, A. (deposition date: 2022-11-22, release date: 2023-01-18, Last modification date: 2024-11-06)
Primary citation	Troisi, R.,Galardo, F.,Ferraro, G.,Sica, F.,Merlino, A. Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study. Inorg.Chem., 62:675-678, 2023 Cited by PubMed Abstract: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation. PubMed: 36602395 DOI: 10.1021/acs.inorgchem.2c04206 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.17 Å)

Structure validation