8BRC

Crystal structure of the adduct between human serum transferrin and cisplatin

8BRC の概要

• エントリーDOI: 10.2210/pdb8brc/pdb
• 分子名称: Serotransferrin, FE (III) ION, MALONATE ION, ... (7 entities in total)
• 機能のキーワード: human serum transferrin, serotransferrin, iron binding transport protein, cisplatin, metal binding, metallodrug, metal transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 75906.74

構造登録者

Troisi, R.,Galardo, F.,Ferraro, G.,Sica, F.,Merlino, A. (登録日: 2022-11-22, 公開日: 2023-01-18, 最終更新日: 2024-11-06)

主引用文献

Troisi, R.,Galardo, F.,Ferraro, G.,Sica, F.,Merlino, A.
Cisplatin Binding to Human Serum Transferrin: A Crystallographic Study.
Inorg.Chem., 62:675-678, 2023

PubMed Abstract: The molecular mechanism of how human serum transferrin (hTF) recognizes cisplatin at the atomic level is still unclear. Here, we report the molecular structure of the adduct formed upon the reaction of hTF with cisplatin. Pt binds the side chain of Met256 (at the N-lobe), without altering the protein overall conformation.

PubMed: 36602395
DOI: 10.1021/acs.inorgchem.2c04206

実験手法

X-RAY DIFFRACTION (3.17 Å)