8BK3
Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with diepoxide ketone 1
Summary for 8BK3
Entry DOI | 10.2210/pdb8bk3/pdb |
Descriptor | L,D-transpeptidase 2, 1-[(2~{S},3~{R})-3-phenyloxiran-2-yl]ethanone, NITRATE ION, ... (7 entities in total) |
Functional Keywords | l, d-transpeptidase, ldtmt2, inhibitor, covalent, antimicrobial protein |
Biological source | Mycobacterium tuberculosis |
Total number of polymer chains | 2 |
Total formula weight | 76738.92 |
Authors | |
Primary citation | de Munnik, M.,Lithgow, J.,Brewitz, L.,Christensen, K.E.,Bates, R.H.,Rodriguez-Miquel, B.,Schofield, C.J. alpha beta , alpha ' beta '-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes. Chem.Commun.(Camb.), 59:12859-12862, 2023 Cited by PubMed: 37815791DOI: 10.1039/d3cc02932h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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