8BJK

X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with an inhibitor CPD11352

Summary for 8BJK

• Entry DOI: 10.2210/pdb8bjk/pdb
• Descriptor: Histone deacetylase 6, ZINC ION, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: histone deacetylase, deacetylation, inhibitor, danio rerio, hydrolase
• Biological source: Danio rerio (zebrafish)
• Total number of polymer chains: 1
• Total formula weight: 40397.54

Authors

Barinka, C.,Motlova, L.,Pavlicek, J. (deposition date: 2022-11-04, release date: 2023-09-06)

• Primary citation: Motlova, L.,Snajdr, I.,Kutil, Z.,Andris, E.,Ptacek, J.,Novotna, A.,Novakova, Z.,Havlinova, B.,Tueckmantel, W.,Draberova, H.,Majer, P.,Schutkowski, M.,Kozikowski, A.,Rulisek, L.,Barinka, C.; Comprehensive Mechanistic View of the Hydrolysis of Oxadiazole-Based Inhibitors by Histone Deacetylase 6 (HDAC6).; Acs Chem.Biol., 18:1594-1610, 2023; PubMed: 37392419; DOI: 10.1021/acschembio.3c00212

Experimental method

X-RAY DIFFRACTION (1.35 Å)