8BJD

Full length structure of LpMIP with bound inhibitor JK095

Summary for 8BJD

• Entry DOI: 10.2210/pdb8bjd/pdb
• Descriptor: Peptidyl-prolyl cis-trans isomerase, (1~{S},5~{S},6~{R})-10-[3,5-bis(chloranyl)phenyl]sulfonyl-5-(hydroxymethyl)-3-(pyridin-2-ylmethyl)-3,10-diazabicyclo[4.3.1]decan-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (6 entities in total)
• Functional Keywords: macrophage, potentiator, soluble, protein., structural protein
• Biological source: Legionella pneumophila
• Total number of polymer chains: 1
• Total formula weight: 23312.11

Authors

Whittaker, J.J.,Guskov, A.,Goretzki, B.,Hellmich, U.A. (deposition date: 2022-11-04, release date: 2023-09-06, Last modification date: 2023-09-13)

• Primary citation: Wiedemann, C.,Whittaker, J.J.,Perez Carrillo, V.H.,Goretzki, B.,Dajka, M.,Tebbe, F.,Harder, J.M.,Krajczy, P.R.,Joseph, B.,Hausch, F.,Guskov, A.,Hellmich, U.A.; Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding.; Int.J.Biol.Macromol., 252:126366-126366, 2023; PubMed: 37633566; DOI: 10.1016/j.ijbiomac.2023.126366

Experimental method

X-RAY DIFFRACTION (2.4 Å)