8BFF
Human PPARgamma in complex with MINCH bound to the AF-2 sub-pocket
Summary for 8BFF
Entry DOI | 10.2210/pdb8bff/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (1~{S},2~{R})-2-[(4~{R})-4-methylheptoxy]carbonylcyclohexane-1-carboxylic acid (3 entities in total) |
Functional Keywords | ppar gamma activation, minch, ligand binding domain, environmental contaminant, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 97522.12 |
Authors | Useini, A.,Straeter, N. (deposition date: 2022-10-25, release date: 2023-03-08, Last modification date: 2024-02-07) |
Primary citation | Useini, A.,Engelberger, F.,Kunze, G.,Strater, N. Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH. Environ Int, 173:107822-107822, 2023 Cited by PubMed: 36841188DOI: 10.1016/j.envint.2023.107822 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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