8BFF

Human PPARgamma in complex with MINCH bound to the AF-2 sub-pocket

8BFF の概要

• エントリーDOI: 10.2210/pdb8bff/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, (1~{S},2~{R})-2-[(4~{R})-4-methylheptoxy]carbonylcyclohexane-1-carboxylic acid (3 entities in total)
• 機能のキーワード: ppar gamma activation, minch, ligand binding domain, environmental contaminant, nuclear protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 97522.12

構造登録者

Useini, A.,Straeter, N. (登録日: 2022-10-25, 公開日: 2023-03-08, 最終更新日: 2024-02-07)

• 主引用文献: Useini, A.,Engelberger, F.,Kunze, G.,Strater, N.; Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH.; Environ Int, 173:107822-107822, 2023; PubMed: 36841188; DOI: 10.1016/j.envint.2023.107822

実験手法

X-RAY DIFFRACTION (2.6 Å)