8BFB
Sarkosyl-extracted AppNL-G-F Abeta42 fibril structure (Methoxy-X04-labelled mice)
Summary for 8BFB
Entry DOI | 10.2210/pdb8bfb/pdb |
EMDB information | 16019 |
Descriptor | Amyloid-beta precursor protein (1 entity in total) |
Functional Keywords | amyloid, fibril, helical, cross-beta, beta amyloid, protein fibril, ex vivo, arctic mutant, alzheimers disease |
Biological source | Mus musculus (house mouse) |
Total number of polymer chains | 10 |
Total formula weight | 44480.25 |
Authors | Wilkinson, M.,Leistner, C.,Burgess, A.,Goodfellow, S.,Deuchars, S.,Ranson, N.A.,Radford, S.E.,Frank, R.A.W. (deposition date: 2022-10-24, release date: 2023-05-31, Last modification date: 2024-07-24) |
Primary citation | Leistner, C.,Wilkinson, M.,Burgess, A.,Lovatt, M.,Goodbody, S.,Xu, Y.,Deuchars, S.,Radford, S.E.,Ranson, N.A.,Frank, R.A.W. The in-tissue molecular architecture of beta-amyloid pathology in the mammalian brain. Nat Commun, 14:2833-2833, 2023 Cited by PubMed: 37198197DOI: 10.1038/s41467-023-38495-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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