8BF2
Human PPARgamma in complex with MEHP bound to the AF-2 and omega sub-pockets
Summary for 8BF2
Entry DOI | 10.2210/pdb8bf2/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2-[(2~{S})-2-ethylhexoxy]carbonylbenzoic acid (3 entities in total) |
Functional Keywords | ppar gamma activation, ligand binding domain, mehp, environmental contaminant, nuclear protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65660.18 |
Authors | Useini, A.,Straeter, N. (deposition date: 2022-10-23, release date: 2023-03-08, Last modification date: 2024-02-07) |
Primary citation | Useini, A.,Engelberger, F.,Kunze, G.,Strater, N. Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH. Environ Int, 173:107822-107822, 2023 Cited by PubMed: 36841188DOI: 10.1016/j.envint.2023.107822 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.18 Å) |
Structure validation
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