8BF2

Human PPARgamma in complex with MEHP bound to the AF-2 and omega sub-pockets

Summary for 8BF2

Entry DOI	10.2210/pdb8bf2/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 2-[(2~{S})-2-ethylhexoxy]carbonylbenzoic acid (3 entities in total)
Functional Keywords	ppar gamma activation, ligand binding domain, mehp, environmental contaminant, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	65660.18
Authors	Useini, A.,Straeter, N. (deposition date: 2022-10-23, release date: 2023-03-08, Last modification date: 2024-02-07)
Primary citation	Useini, A.,Engelberger, F.,Kunze, G.,Strater, N. Structural basis of the activation of PPAR gamma by the plasticizer metabolites MEHP and MINCH. Environ Int, 173:107822-107822, 2023 Cited by PubMed: 36841188 DOI: 10.1016/j.envint.2023.107822 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation