8BF2

Human PPARgamma in complex with MEHP bound to the AF-2 and omega sub-pockets

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor gamma	polymer	283	32412.6	2	UniProt (P37231) Pfam (PF00104)	Homo sapiens (human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	C, D, E (A, B)	2-[(2~{S})-2-ethylhexoxy]carbonylbenzoic acid	non-polymer		278.3	3	Chemie (QGL)
3	F, G (A, B)	water	water		18.0	184	Chemie (HOH)

Sequence modifications

A, B: 206 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 195	-	initiating methionine
Arg 196	-	expression tag
Gly 197	-	expression tag
Ser 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag
His 204	-	expression tag
Gly 205	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64825.2
Non-Polymers*	Number of molecules	3
	Total formula weight	835.0
All*	Total formula weight	65660.2

*Water molecules are not included.