8B7W

Complex IL-17A/anti-IL-17A-76

8B7W の概要

• エントリーDOI: 10.2210/pdb8b7w/pdb
• 分子名称: anti-IL-17A-76, Interleukin-17A, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: interleukin 17a in complex with vhh domain, netakimab, crystal structure., immune system, inhibitor, immune system/inhibitor, immune system-inhibitor complex
• 由来する生物種: Lama glama; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27606.14

構造登録者

Kostareva, O.S.,Svoeglazova, A.,Kolyadenko, I.A.,Dzhus, U.F.,Tishchenko, S.V.,Gabdulkhakov, A.G. (登録日: 2022-10-03, 公開日: 2022-12-28, 最終更新日: 2024-11-13)

主引用文献

Kostareva, O.,Svoeglazova, A.,Kolyadenko, I.,Nikulin, A.,Evdokimov, S.,Dzhus, U.,Gabdulkhakov, A.,Tishchenko, S.
Two Epitope Regions Revealed in the Complex of IL-17A and Anti-IL-17A V H H Domain.
Int J Mol Sci, 23:-, 2022

PubMed Abstract: Interleukin-17 (IL-17) is a cytokine produced by the Th17 cells. It is involved in chronic inflammation in patients with autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and psoriasis. The antibodies targeting IL-17 and/or IL-17R are therapy tools for these diseases. Netakimab is an IL-17A-specific antibody containing a VH derivative domain and a VL variable domain. We have determined the crystal structure of the IL-17A-specific VH domain in complex with IL-17A at 2.85 Å resolution. Certain amino acid residues of the three complementary-determining regions of the VH domain form a network of solvent-inaccessible hydrogen bonds with two epitope regions of IL-17A. The β-turn of IL-17A, which forms the so-called epitope-1, appears to be the main region of IL-17A interaction with the antibody. Contacts formed by the IL-17A mobile C-terminal region residues (epitope-2) further stabilize the antibody-antigen complex.

PubMed: 36499233
DOI: 10.3390/ijms232314904

実験手法

X-RAY DIFFRACTION (2.85 Å)