8B7D

Luminal domain of TMEM106B

Summary for 8B7D

Entry DOI	10.2210/pdb8b7d/pdb
Descriptor	Transmembrane protein 106B, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	luminal domain, fibronectin type iii (fn3), 7-bladed beta-sandwich fold, receptor binding, sars cov2, covid19, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	23657.52
Authors	Pye, V.E.,Roustan, C.,Cherepanov, P. (deposition date: 2022-09-29, release date: 2023-07-19, Last modification date: 2024-05-01)
Primary citation	Baggen, J.,Jacquemyn, M.,Persoons, L.,Vanstreels, E.,Pye, V.E.,Wrobel, A.G.,Calvaresi, V.,Martin, S.R.,Roustan, C.,Cronin, N.B.,Reading, E.,Thibaut, H.J.,Vercruysse, T.,Maes, P.,De Smet, F.,Yee, A.,Nivitchanyong, T.,Roell, M.,Franco-Hernandez, N.,Rhinn, H.,Mamchak, A.A.,Ah Young-Chapon, M.,Brown, E.,Cherepanov, P.,Daelemans, D. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry. Cell, 186:3427-, 2023 Cited by PubMed: 37421949 DOI: 10.1016/j.cell.2023.06.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.59 Å)

Structure validation