8B5C
Human BRD4 bromdomain 1 in complex with a H4 peptide containing ApmTri (H4K5/8ApmTri)
Summary for 8B5C
Entry DOI | 10.2210/pdb8b5c/pdb |
Descriptor | Bromodomain-containing protein 4, H4K5/8ApmTri (3 entities in total) |
Functional Keywords | apmtri, acetyl-lysine mimic, bet-bromodomain, histone-peptide, peptide binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 16556.02 |
Authors | Braun, M.B.,Bartlick, N.,Stehle, T. (deposition date: 2022-09-22, release date: 2023-01-11, Last modification date: 2024-02-07) |
Primary citation | Kirchgassner, S.,Braun, M.B.,Bartlick, N.,Koc, C.,Reinkemeier, C.D.,Lemke, E.A.,Stehle, T.,Schwarzer, D. Synthesis, Biochemical Characterization, and Genetic Encoding of a 1,2,4-Triazole Amino Acid as an Acetyllysine Mimic for Bromodomains of the BET Family. Angew.Chem.Int.Ed.Engl., 62:e202215460-e202215460, 2023 Cited by PubMed: 36585954DOI: 10.1002/anie.202215460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.58 Å) |
Structure validation
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