8B2N

Potempin A (PotA) from Tannerella forsythia in complex with the catalytic domain of human MMP-12

Summary for 8B2N

• Entry DOI: 10.2210/pdb8b2n/pdb
• Related: 8B2M
• Descriptor: Macrophage metalloelastase, Tannerella forsythia potempin A (PotA), CALCIUM ION, ... (5 entities in total)
• Functional Keywords: metallopeptidase inhibitor, hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 56989.57

Authors

Potempa, J.,Ksiazek, M.,Goulas, T.,Cuppari, A.,Rodriguez-Banqueri, A.,Arolas, J.L.,Lopez-Pelegrin, M.,Garcia-Ferrer, I.,Guevara, T. (deposition date: 2022-09-14, release date: 2022-12-21, Last modification date: 2024-02-07)

• Primary citation: Ksiazek, M.,Goulas, T.,Mizgalska, D.,Rodriguez-Banqueri, A.,Eckhard, U.,Veillard, F.,Waligorska, I.,Benedyk-Machaczka, M.,Sochaj-Gregorczyk, A.M.,Madej, M.,Thogersen, I.B.,Enghild, J.J.,Cuppari, A.,Arolas, J.L.,de Diego, I.,Lopez-Pelegrin, M.,Garcia-Ferrer, I.,Guevara, T.,Dive, V.,Zani, M.L.,Moreau, T.,Potempa, J.,Gomis-Ruth, F.X.; A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.; Chem Sci, 14:869-888, 2023; PubMed: 36755705; DOI: 10.1039/d2sc04166a

Experimental method

X-RAY DIFFRACTION (1.85 Å)