8B07

Crystal structure of monkeypox virus methyltransferase VP39 in complex with sinefungin

Summary for 8B07

• Entry DOI: 10.2210/pdb8b07/pdb
• Descriptor: Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase, SINEFUNGIN (3 entities in total)
• Functional Keywords: viral, methyltransferase, vp39, monkeypox, capping, enzyme, viral protein
• Biological source: Monkeypox virus (monkeypox)
• Total number of polymer chains: 2
• Total formula weight: 72661.76

Authors

Silhan, J.,Klima, M.,Boura, E. (deposition date: 2022-09-07, release date: 2023-04-05, Last modification date: 2024-02-07)

• Primary citation: Silhan, J.,Klima, M.,Otava, T.,Skvara, P.,Chalupska, D.,Chalupsky, K.,Kozic, J.,Nencka, R.,Boura, E.; Discovery and structural characterization of monkeypox virus methyltransferase VP39 inhibitors reveal similarities to SARS-CoV-2 nsp14 methyltransferase.; Nat Commun, 14:2259-2259, 2023; PubMed: 37080993; DOI: 10.1038/s41467-023-38019-1

Experimental method

X-RAY DIFFRACTION (2.05 Å)