8AYF
Crystal structure of human Sphingosine-1-phosphate lyase 1
Summary for 8AYF
Entry DOI | 10.2210/pdb8ayf/pdb |
Descriptor | Sphingosine-1-phosphate lyase 1, ACETATE ION, GLYCEROL, ... (4 entities in total) |
Functional Keywords | s1p, lipid, lyase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 110298.79 |
Authors | Giardina, G.,Catalano, F.,Pampalone, G.,Cellini, B. (deposition date: 2022-09-02, release date: 2023-09-13, Last modification date: 2024-01-03) |
Primary citation | Cellini, B.,Pampalone, G.,Camaioni, E.,Pariano, M.,Catalano, F.,Zelante, T.,Dindo, M.,Macchioni, L.,Di Veroli, A.,Galarini, R.,Paoletti, F.,Davidescu, M.,Stincardini, C.,Vascelli, G.,Bellet, M.M.,Saba, J.,Giovagnoli, S.,Giardina, G.,Romani, L.,Costantini, C. Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study. Sci Rep, 13:22692-22692, 2023 Cited by PubMed: 38123809DOI: 10.1038/s41598-023-50121-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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