8AY1

Crystal structure of the C. elegans POFUT2 (CePoFUT2) triple mutant (R298K-R299K-A418C) in complex with the Rattus norvegicus TSR4 single mutant (E10C) from F-spondin

Summary for 8AY1

Entry DOI	10.2210/pdb8ay1/pdb
Descriptor	GDP-fucose protein O-fucosyltransferase 2,Spondin-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywords	pofut2, tsr, water molecules, protein o-fucosylation, transferase
Biological source	Caenorhabditis elegans More
Total number of polymer chains	2
Total formula weight	109010.33
Authors	Hurtado-Guerrero, R.,Merino, P. (deposition date: 2022-09-01, release date: 2022-10-26, Last modification date: 2024-01-31)
Primary citation	Sanz-Martinez, I.,Garcia-Garcia, A.,Tejero, T.,Hurtado-Guerrero, R.,Merino, P. The Essential Role of Water Molecules in the Reaction Mechanism of Protein O-Fucosyltransferase 2. Angew.Chem.Int.Ed.Engl., 61:e202213610-e202213610, 2022 Cited by PubMed: 36260536 DOI: 10.1002/anie.202213610 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation