8AV9

INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH COMPOUND 1

8AV9 の概要

• エントリーDOI: 10.2210/pdb8av9/pdb
• 分子名称: Induced myeloid leukemia cell differentiation protein Mcl-1, Fab Heavy Chain, Fab Light Chain, ... (5 entities in total)
• 機能のキーワード: mcl1, fab, macrocycle, mcl1-fab_55_c6his, immune system, apoptosis
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68647.95

構造登録者

Hargreaves, D. (登録日: 2022-08-26, 公開日: 2023-05-24, 最終更新日: 2024-05-01)

• 主引用文献: Hargreaves, D.,Carbajo, R.J.,Bodnarchuk, M.S.,Embrey, K.,Rawlins, P.B.,Packer, M.,Degorce, S.L.,Hird, A.W.,Johannes, J.W.,Chiarparin, E.,Schade, M.; Design of rigid protein-protein interaction inhibitors enables targeting of undruggable Mcl-1.; Proc.Natl.Acad.Sci.USA, 120:e2221967120-e2221967120, 2023; PubMed: 37186857; DOI: 10.1073/pnas.2221967120

実験手法