8AUW

Cryo-EM structure of human BIRC6 in complex with SMAC.

This is a non-PDB format compatible entry.

Summary for 8AUW

• Entry DOI: 10.2210/pdb8auw/pdb
• Related: 8ATU 8ATX 8AUK
• EMDB information: 15675
• Descriptor: Baculoviral IAP repeat-containing protein 6, Diablo IAP-binding mitochondrial protein, ZINC ION (3 entities in total)
• Functional Keywords: e3 ubiquitin ligase, e2/e3 hybrid, inhibitor of apoptosis protein, ligase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 1105723.01

Authors

Ehrmann, J.F.,Grabarczyk, D.B.,Clausen, T. (deposition date: 2022-08-25, release date: 2023-02-15, Last modification date: 2023-05-24)

• Primary citation: Ehrmann, J.F.,Grabarczyk, D.B.,Heinke, M.,Deszcz, L.,Kurzbauer, R.,Hudecz, O.,Shulkina, A.,Gogova, R.,Meinhart, A.,Versteeg, G.A.,Clausen, T.; Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.; Science, 379:1117-1123, 2023; PubMed: 36758105; DOI: 10.1126/science.ade8873

Experimental method

ELECTRON MICROSCOPY (7.2 Å)