8AS0

PD-1 extracellular domain in complex with Fab fragment from D12 antibody

8AS0 の概要

• エントリーDOI: 10.2210/pdb8as0/pdb
• 分子名称: D12 antibody light chain, Fab fragment, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: monoclonal antibodies, phage display technology, antibody library, human pd-1, immunotherapy, antitumor protein
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 24
• 化学式量合計: 539786.73

構造登録者

Ongaro, T.,Scietti, L.,Pluss, L.,Peissert, F.,Villa, A.,Puca, E.,De Luca, R.,Neri, D.,Forneris, F. (登録日: 2022-08-17, 公開日: 2022-11-23, 最終更新日: 2024-01-31)

• 主引用文献: Peissert, F.,Pluss, L.,Giudice, A.M.,Ongaro, T.,Villa, A.,Elsayed, A.,Nadal, L.,Dakhel Plaza, S.,Scietti, L.,Puca, E.,De Luca, R.,Forneris, F.,Neri, D.; Selection of a PD-1 blocking antibody from a novel fully human phage display library.; Protein Sci., 31:e4486-e4486, 2022; PubMed: 36317676; DOI: 10.1002/pro.4486

実験手法

X-RAY DIFFRACTION (3.5 Å)