8ARJ

Anaplastic Lymphoma Kinase with a novel carboline inhibitor

Summary for 8ARJ

Entry DOI	10.2210/pdb8arj/pdb
Descriptor	ALK tyrosine kinase receptor, 3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{H}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one (3 entities in total)
Functional Keywords	inhibitor, alk, kinase, antitumor, antitumor protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36461.89
Authors	Mologni, L.,Scapozza, L.,Gambacorti-Passerini, C.,Tardy, S.,Goekjian, P.,Robinson, C.,Brown, D. (deposition date: 2022-08-17, release date: 2022-09-14, Last modification date: 2024-01-31)
Primary citation	Mologni, L.,Tardy, S.,Zambon, A.,Orsato, A.,Bisson, W.H.,Ceccon, M.,Viltadi, M.,D'Attoma, J.,Pannilunghi, S.,Vece, V.,Bertho, J.,Goekjian, P.,Scapozza, L.,Gambacorti-Passerini, C. Discovery of Novel alpha-Carboline Inhibitors of the Anaplastic Lymphoma Kinase. Acs Omega, 7:17083-17097, 2022 Cited by PubMed: 35647450 DOI: 10.1021/acsomega.2c00507 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.645 Å)

Structure validation