8ARJ
Anaplastic Lymphoma Kinase with a novel carboline inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 321 | 36022.3 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | 3-(dimethylamino)-1-[3-[4-(4-methylpiperazin-1-yl)phenyl]-9~{H}-pyrido[2,3-b]indol-6-yl]prop-2-en-1-one | non-polymer | 439.6 | 1 | Chemie (NRR) | |||
| 3 | C (A) | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1091 | - | expression tag |
| Ser 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36022.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 439.6 | |
| All* | Total formula weight | 36461.9 |
