8AJ8

Structure of p110 gamma bound to the p84 regulatory subunit

8AJ8 の概要

• エントリーDOI: 10.2210/pdb8aj8/pdb
• 分子名称: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, Phosphoinositide 3-kinase regulatory subunit 6 (2 entities in total)
• 機能のキーワード: pi3k, pik3cg, pik3r6, phosphoinositide 3-kinase, p110, p84, signaling protein
• 由来する生物種: Sus scrofa (pig); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 846402.87

構造登録者

Burke, J.E.,Williams, R.L.,Zhang, X. (登録日: 2022-07-27, 公開日: 2023-03-22, 最終更新日: 2024-02-07)

• 主引用文献: Rathinaswamy, M.K.,Jenkins, M.L.,Duewell, B.R.,Zhang, X.,Harris, N.J.,Evans, J.T.,Stariha, J.T.B.,Dalwadi, U.,Fleming, K.D.,Ranga-Prasad, H.,Yip, C.K.,Williams, R.L.,Hansen, S.D.,Burke, J.E.; Molecular basis for differential activation of p101 and p84 complexes of PI3K gamma by Ras and GPCRs.; Cell Rep, 42:112172-112172, 2023; PubMed: 36842083; DOI: 10.1016/j.celrep.2023.112172

実験手法

X-RAY DIFFRACTION (8.5 Å)