8AHV

Crystal structure of human cathepsin L in complex with calpain inhibitor XII

Summary for 8AHV

• Entry DOI: 10.2210/pdb8ahv/pdb
• Related: 7ZS7 7ZVF 8A5B
• Descriptor: Cathepsin L, TRIETHYLENE GLYCOL, (phenylmethyl) ~{N}-[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S},3~{S})-2-oxidanyl-1-oxidanylidene-1-(pyridin-2-ylmethylamino)hexan-3-yl]amino]pentan-2-yl]carbamate, ... (7 entities in total)
• Functional Keywords: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 99976.81

Authors

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-07-22, release date: 2023-08-02)

• Primary citation: Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A.; Crystal structure of human cathepsin L in complex with calpain inhibitor XII; To be published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)