8AG6
human MutSalpha (MSH2/MSH6) binding to DNA with a GT mismatch
Summary for 8AG6
Entry DOI | 10.2210/pdb8ag6/pdb |
EMDB information | 15417 15518 15519 |
Descriptor | DNA mismatch repair protein Msh2, DNA mismatch repair protein Msh6, DNA (50-MER), ... (6 entities in total) |
Functional Keywords | dna mismatch repair, mmr, mutsa, lynch syndrome, dna binding protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 294902.44 |
Authors | Bruekner, S.R.,Sixma, T.K. (deposition date: 2022-07-19, release date: 2023-01-25, Last modification date: 2024-07-24) |
Primary citation | Bruekner, S.R.,Pieters, W.,Fish, A.,Liaci, A.M.,Scheffers, S.,Rayner, E.,Kaldenbach, D.,Drost, L.,Dekker, M.,van Hees-Stuivenberg, S.,Delzenne-Goette, E.,de Konink, C.,Houlleberghs, H.,Dubbink, H.J.,AlSaegh, A.,de Wind, N.,Forster, F.,Te Riele, H.,Sixma, T.K. Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding. Nucleic Acids Res., 51:1173-1188, 2023 Cited by PubMed: 36715327DOI: 10.1093/nar/gkad015 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
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