8AEV

Human acetylcholinesterase in complex with N,N,N-trimethyl-2-oxo-2-(2-(pyridin-2-ylmethylene)hydrazineyl)ethan-1-aminium

Summary for 8AEV

• Entry DOI: 10.2210/pdb8aev/pdb
• Related: 8AEN
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: inhibitor, complex, zinc, acetylcholinesterase, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 124979.21

Authors

Nachon, F.,Dias, J.,Brazzolotto, X. (deposition date: 2022-07-13, release date: 2023-06-14, Last modification date: 2024-02-07)

• Primary citation: Nachon, F.,Brazzolotto, X.,Dias, J.,Courageux, C.,Drozdz, W.,Cao, X.Y.,Stefankiewicz, A.R.,Lehn, J.M.; Grid-Type Quaternary Metallosupramolecular Compounds Inhibit Human Cholinesterases through Dynamic Multivalent Interactions.; Chembiochem, 23:e202200456-e202200456, 2022; PubMed: 36193860; DOI: 10.1002/cbic.202200456

Experimental method

X-RAY DIFFRACTION (2.89 Å)