8AEK
Structure of Compound 14 bound to CK2alpha
Summary for 8AEK
| Entry DOI | 10.2210/pdb8aek/pdb |
| Descriptor | Casein kinase II subunit alpha, 2-[5-(trifluoromethyl)-1H-indol-3-yl]ethanenitrile, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total) |
| Functional Keywords | fragment based, transferase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 39939.89 |
| Authors | Brear, P.,Fusco, C.,Atkinson, E.,Iegre, J.,Francis-Newton, N.,Venkotaraman, A.,Spring, D.,Hyvonen, M. (deposition date: 2022-07-13, release date: 2022-10-12, Last modification date: 2024-02-07) |
| Primary citation | Brear, P.,De Fusco, C.,Atkinson, E.L.,Iegre, J.,Francis-Newton, N.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R. A fragment-based approach leading to the discovery of inhibitors of CK2 alpha with a novel mechanism of action. Rsc Med Chem, 13:1420-1426, 2022 Cited by PubMed: 36426237DOI: 10.1039/d2md00161f PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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