8ADM

Ternary complex of 14-3-3 sigma, Usp8pS718 phosphopeptide and small molecule stabilizer

Summary for 8ADM

Entry DOI	10.2210/pdb8adm/pdb
Descriptor	14-3-3 protein sigma, Ubiquitin carboxyl-terminal hydrolase 8, 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide, ... (4 entities in total)
Functional Keywords	14-3-3 sigma, usp8, small molecule stabilizer, signaling protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	28035.98
Authors	Centorrino, F.,Ottmann, C. (deposition date: 2022-07-08, release date: 2023-04-26, Last modification date: 2024-02-07)
Primary citation	Kenanova, D.N.,Visser, E.J.,Virta, J.M.,Sijbesma, E.,Centorrino, F.,Vickery, H.R.,Zhong, M.,Neitz, R.J.,Brunsveld, L.,Ottmann, C.,Arkin, M.R. A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers. Acs Cent.Sci., 9:937-946, 2023 Cited by PubMed: 37252362 DOI: 10.1021/acscentsci.2c01449 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation