8A9G

Binary complex of 14-3-3 zeta Glucocorticoid Receptor (GR) pT524 peptide stabilised by (R)-para chloropyrrolidone1

Summary for 8A9G

• Entry DOI: 10.2210/pdb8a9g/pdb
• Related: 6YO8
• Descriptor: 14-3-3 protein zeta/delta, Glucocorticoid receptor, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
• Functional Keywords: 14-3-3 protein zeta/delta, glucocorticoid receptor, (r)-para chloropyrrolidone1, protein-peptide complex, protein-protein interaction, ppi stabilisation, molecular glue, pyrrolidone1 analogue, protein binding
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 57792.18

Authors

Munier, C.C.,Edman, K.,Perry, M.W.D.,Ottmann, C. (deposition date: 2022-06-28, release date: 2022-12-28, Last modification date: 2024-01-31)

• Primary citation: Pallesen, J.S.,Munier, C.C.,Bosica, F.,Andrei, S.A.,Edman, K.,Gunnarsson, A.,La Sala, G.,Putra, O.D.,Srdanovic, S.,Wilson, A.J.,Wissler, L.,Ottmann, C.,Perry, M.W.D.,O'Mahony, G.; Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein Interaction.; J.Med.Chem., 65:16818-16828, 2022; PubMed: 36484727; DOI: 10.1021/acs.jmedchem.2c01635

Experimental method

X-RAY DIFFRACTION (1.961 Å)