8A8Z
Crystal structure of Danio rerio HDAC6 CD2 in complex with in situ enzymatically hydrolyzed DFMO-based ITF5924
Summary for 8A8Z
| Entry DOI | 10.2210/pdb8a8z/pdb |
| Descriptor | Histone deacetylase 6, 4-[[4-[4-(imidazolidin-2-ylideneamino)phenyl]-1,2,3-triazol-1-yl]methyl]benzohydrazide, ZINC ION, ... (5 entities in total) |
| Functional Keywords | histone deacetylase, complex with hydrazide, hydrolase, non-hydroxamate zinc binding group, mechanism-based inhibitor |
| Biological source | Danio rerio (zebrafish) |
| Total number of polymer chains | 2 |
| Total formula weight | 81725.11 |
| Authors | Zrubek, K.,Sandrone, G.,Cukier, C.D.,Stevenazzi, A. (deposition date: 2022-06-27, release date: 2023-01-25, Last modification date: 2024-02-07) |
| Primary citation | Cellupica, E.,Caprini, G.,Cordella, P.,Cukier, C.,Fossati, G.,Marchini, M.,Rocchio, I.,Sandrone, G.,Vanoni, M.A.,Vergani, B.,Zrubek, K.,Stevenazzi, A.,Steinkuhler, C. Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity. J.Biol.Chem., 299:102800-102800, 2022 Cited by PubMed: 36528061DOI: 10.1016/j.jbc.2022.102800 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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