8A8Z
Crystal structure of Danio rerio HDAC6 CD2 in complex with in situ enzymatically hydrolyzed DFMO-based ITF5924
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone deacetylase 6 | polymer | 365 | 40342.5 | 2 | UniProt (F8W4B7) Pfam (PF00850) | Danio rerio (zebrafish) | |
| 2 | C, G (A, B) | 4-[[4-[4-(imidazolidin-2-ylideneamino)phenyl]-1,2,3-triazol-1-yl]methyl]benzohydrazide | non-polymer | 376.4 | 2 | Chemie (LDL) | |||
| 3 | D, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E, F, I, J (A, B) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 686 | Chemie (HOH) |
Sequence modifications
A, B: 440 - 798 (UniProt: F8W4B7)
| PDB | External Database | Details |
|---|---|---|
| Gly 434 | - | cloning artifact |
| Ser 435 | - | cloning artifact |
| Asn 436 | - | cloning artifact |
| Ala 437 | - | cloning artifact |
| Gly 438 | - | cloning artifact |
| Gly 439 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80685.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1040.0 | |
| All* | Total formula weight | 81725.1 |
