8A5B

Crystal structure of human cathepsin L in complex with covalently bound MG-101

Summary for 8A5B

Entry DOI	10.2210/pdb8a5b/pdb
Related	7QKD 7ZS7 7ZVF
Related PRD ID	PRD_002460
Descriptor	Cathepsin L, Calpain Inhibitor I, TRIETHYLENE GLYCOL, ... (6 entities in total)
Functional Keywords	cystein protease, drug target, lysosome, virus cell entry, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	98749.37
Authors	Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-06-14, release date: 2023-07-05, Last modification date: 2024-05-22)
Primary citation	Falke, S.,Lieske, J.,Herrmann, A.,Loboda, J.,Karnicar, K.,Gunther, S.,Reinke, P.Y.A.,Ewert, W.,Usenik, A.,Lindic, N.,Sekirnik, A.,Dretnik, K.,Tsuge, H.,Turk, V.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A. Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors. J.Med.Chem., 67:7048-7067, 2024 Cited by PubMed: 38630165 DOI: 10.1021/acs.jmedchem.3c02351 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation