8A5B

Crystal structure of human cathepsin L in complex with covalently bound MG-101

Summary for 8A5B

• Entry DOI: 10.2210/pdb8a5b/pdb
• Related: 7QKD 7ZS7 7ZVF
• Related PRD ID: PRD_002460
• Descriptor: Cathepsin L, Calpain Inhibitor I, TRIETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: cystein protease, drug target, lysosome, virus cell entry, hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 98749.37

Authors

Falke, S.,Lieske, J.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Turk, D.,Meents, A. (deposition date: 2022-06-14, release date: 2023-07-05, Last modification date: 2024-02-07)

• Primary citation: Falke, S.,Lieske, J.,Herrmann, A.,Guenther, S.,Reinke, P.Y.A.,Ewert, W.,Loboda, J.,Karnicar, K.,Usenik, A.,Lindic, N.,Sekirnik, A.,Chapman, H.N.,Hinrichs, W.,Ebert, G.,Turk, D.,Meents, A.; Structural elucidation of antiviral cathepsin L inhibitors; To be published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)