8A5B
Crystal structure of human cathepsin L in complex with covalently bound MG-101
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) In PDB | Homo sapiens (human) | |
| 2 | E, F, G, H | Calpain Inhibitor I | polymer | 4 | 385.5 | 4 | BIRD (PRD_002460) | synthetic construct | MG-101 |
| 3 | A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 4 | A, B, D | SODIUM ION | non-polymer | 23.0 | 4 | Chemie (NA) | |||
| 5 | C, D | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 3 | Chemie (PEG) | |||
| 6 | water | water | 18.0 | 248 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 98188.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 560.5 | |
| All* | Total formula weight | 98749.4 |
