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8A5B

Crystal structure of human cathepsin L in complex with covalently bound MG-101

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Cathepsin Lpolymer22024161.74UniProt (P07711)
Pfam (PF00112)
Homo sapiens (human)
2E, F, G, H
(E, F, G, H)
Calpain Inhibitor Ipolymer4385.54BIRD (PRD_002460)synthetic constructMG-101
3I
(A)
TRIETHYLENE GLYCOLnon-polymer150.21Chemie (PGE)
4J, K, L, P
(A, B, D)
SODIUM IONnon-polymer23.04Chemie (NA)
5M, N, O
(C, D)
DI(HYDROXYETHYL)ETHERnon-polymer106.13Chemie (PEG)
6Q, R, S, T, U
(A, B, C, D, F)
waterwater18.0248Chemie (HOH)
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
PDBExternal DatabaseDetails
Ala 110Thr 223engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight98188.9
Non-Polymers*Number of molecules8
Total formula weight560.5
All*Total formula weight98749.4
*Water molecules are not included.

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PDB entries from 2025-07-23

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