8X52
Cryo-EM structure of human gamma-secretase in complex with Abeta49
Summary for 8X52
Entry DOI | 10.2210/pdb8x52/pdb |
EMDB information | 38059 |
Descriptor | Amyloid-beta precursor protein, CHOLESTEROL, Nicastrin, ... (10 entities in total) |
Functional Keywords | intramembrane protease, gamma-secretase, presenilin-1, membrane protein, membrane protein-hydrolase complex |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 192756.36 |
Authors | |
Primary citation | Guo, X.,Li, H.,Yan, C.,Lei, J.,Zhou, R.,Shi, Y. Molecular mechanism of substrate recognition and cleavage by human gamma-secretase. Science, 384:1091-1095, 2024 Cited by PubMed: 38843321DOI: 10.1126/science.adn5820 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
Download full validation report