8W2F
Plasmodium falciparum 20S proteasome bound to an inhibitor
This is a non-PDB format compatible entry.
Summary for 8W2F
Entry DOI | 10.2210/pdb8w2f/pdb |
EMDB information | 43746 |
Descriptor | Proteasome endopeptidase complex, Proteasome subunit beta, Proteasome subunit beta type, ... (15 entities in total) |
Functional Keywords | malaria, plasmodium falciparum, proteasome, drug discovery, cytosolic protein, cytosolic protein-inhibitor complex, cytosolic protein/inhibitor |
Biological source | Plasmodium falciparum 3D7 More |
Total number of polymer chains | 28 |
Total formula weight | 767152.69 |
Authors | Han, Y.,Deng, X.,Ray, S.,Chen, Z.,Phillips, M. (deposition date: 2024-02-20, release date: 2024-07-31, Last modification date: 2024-09-04) |
Primary citation | Lawong, A.,Gahalawat, S.,Ray, S.,Ho, N.,Han, Y.,Ward, K.E.,Deng, X.,Chen, Z.,Kumar, A.,Xing, C.,Hosangadi, V.,Fairhurst, K.J.,Tashiro, K.,Liszczak, G.,Shackleford, D.M.,Katneni, K.,Chen, G.,Saunders, J.,Crighton, E.,Casas, A.,Robinson, J.J.,Imlay, L.S.,Zhang, X.,Lemoff, A.,Zhao, Z.,Angulo-Barturen, I.,Jimenez-Diaz, M.B.,Wittlin, S.,Campbell, S.F.,Fidock, D.A.,Laleu, B.,Charman, S.A.,Ready, J.M.,Phillips, M.A. Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria. Cell Chem Biol, 31:1503-, 2024 Cited by PubMed: 39084225DOI: 10.1016/j.chembiol.2024.07.001 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
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