8VQ2

HSV1 polymerase ternary complex with dsDNA and compound 44

This is a non-PDB format compatible entry.

Summary for 8VQ2

• Entry DOI: 10.2210/pdb8vq2/pdb
• Descriptor: DNA polymerase, DNA (5'-D(P*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*T)-3'), DNA (5'-D(P*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), ... (4 entities in total)
• Functional Keywords: herpesvirus polymerase complex inhibitor, transferase
• Biological source: Human alphaherpesvirus 1 (Herpes simplex virus type 1); More
• Total number of polymer chains: 6
• Total formula weight: 277265.65

Authors

Hayes, R.P.,Heo, M.R.,Plotkin, M. (deposition date: 2024-01-17, release date: 2024-08-28)

• Primary citation: Plotkin, M.A.,Labroli, M.,Schubert, J.,Shaw, A.,Schlegel, K.S.,Berger, R.,Cooke, A.J.,Hayes, R.P.,Armacost, K.A.,Kinek, K.,Krosky, P.,Burlein, C.,Meng, S.,DiNunzio, E.,Murray, E.M.,Agrawal, S.,Madeira, M.,Flattery, A.,Yao, H.,Leithead, A.,Rose 2nd, W.A.,Cox, C.,Tellers, D.M.,McKenna, P.M.,Raheem, I.; Discovery of Broad-Spectrum Herpes Antiviral Oxazolidinone Amide Derivatives and Their Structure-Activity Relationships.; Acs Med.Chem.Lett., 15:1232-1241, 2024; PubMed: 39140041; DOI: 10.1021/acsmedchemlett.4c00117

Experimental method

X-RAY DIFFRACTION (3.829 Å)