8VJ7
GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2
This is a non-PDB format compatible entry.
Summary for 8VJ7
Entry DOI | 10.2210/pdb8vj7/pdb |
EMDB information | 43276 |
Descriptor | Isoform Flip of Glutamate receptor 2, GLUTAMIC ACID, 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline (3 entities in total) |
Functional Keywords | ligand gated ion channel, ionotropic glutamate receptor, allosteric inhibition, membrane protein, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Rattus norvegicus (Norway rat) |
Total number of polymer chains | 4 |
Total formula weight | 358693.64 |
Authors | Hale, W.D.,Montano Romero, A.,Huganir, R.L.,Twomey, E.C. (deposition date: 2024-01-05, release date: 2024-06-05, Last modification date: 2024-06-19) |
Primary citation | Hale, W.D.,Montano Romero, A.,Gonzalez, C.U.,Jayaraman, V.,Lau, A.Y.,Huganir, R.L.,Twomey, E.C. Allosteric competition and inhibition in AMPA receptors. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 38834914DOI: 10.1038/s41594-024-01328-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.85 Å) |
Structure validation
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