8UKV
Crystal structure of nanobody/VHH domain of 34E5 in complex with the extracellular region of the epidermal growth factor variant III (EGFRvIII)
Summary for 8UKV
Entry DOI | 10.2210/pdb8ukv/pdb |
Related | 8UKW 8UKX |
Descriptor | Epidermal growth factor receptor, Nanobody/VHH domain 34E5, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total) |
Functional Keywords | cell surface receptor, glycoprotein, extracellular, glioblastoma, oncogenic variant, nanobody, vhh domain, camelid vh domain, antibody, antigen, antibody complex, transferase-immune system complex, transferase, transferase/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 111436.20 |
Authors | Stayrook, S.E.,Ferguson, K.M.,Bagchi, A. (deposition date: 2023-10-15, release date: 2024-06-19, Last modification date: 2024-09-25) |
Primary citation | Bagchi, A.,Stayrook, S.E.,Xenaki, K.T.,Starbird, C.A.,Doulkeridou, S.,El Khoulati, R.,Roovers, R.C.,Schmitz, K.R.,van Bergen En Henegouwen, P.M.P.,Ferguson, K.M. Structural insights into the role and targeting of EGFRvIII. Structure, 32:1367-, 2024 Cited by PubMed: 38908376DOI: 10.1016/j.str.2024.05.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
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