8UH6
Degrader-induced complex between PTPN2 and CRBN-DDB1
Summary for 8UH6
Entry DOI | 10.2210/pdb8uh6/pdb |
EMDB information | 42247 |
Descriptor | DNA damage-binding protein 1, Protein cereblon, Tyrosine-protein phosphatase non-receptor type 2, ... (5 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 219118.76 |
Authors | Catalano, C.,Bratkowski, M.,Scapin, G.,Hao, Q. (deposition date: 2023-10-06, release date: 2024-09-11) |
Primary citation | Hao, Q.,Rathinaswamy, M.K.,Klinge, K.L.,Bratkowski, M.,Mafi, A.,Baumgartner, C.K.,Hamel, K.M.,Veits, G.K.,Jain, R.,Catalano, C.,Fitzgerald, M.,Hird, A.W.,Park, E.,Vora, H.U.,Henderson, J.A.,Longenecker, K.,Hutchins, C.W.,Qiu, W.,Scapin, G.,Sun, Q.,Stoll, V.S.,Sun, C.,Li, P.,Eaton, D.,Stokoe, D.,Fisher, S.L.,Nasveschuk, C.G.,Paddock, M.,Kort, M.E. Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. Commun Chem, 7:183-183, 2024 Cited by PubMed: 39152201DOI: 10.1038/s42004-024-01263-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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