8UH6
Degrader-induced complex between PTPN2 and CRBN-DDB1
Functional Information from PROSITE/UniProt
site_id | PS00383 |
Number of Residues | 11 |
Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHCsaGigRSG |
Chain | Residue | Details |
C | ILE214-GLY224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 |
Chain | Residue | Details |
C | CYS216 | |
B | CYS326 | |
B | HIS378 | |
B | TRP380 | |
B | TRP386 | |
B | CYS391 | |
B | CYS394 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
C | ASP182 | |
C | CYS216 | |
C | GLN260 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P18031 |
Chain | Residue | Details |
C | TYR22 | |
C | TYR68 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P18031 |
Chain | Residue | Details |
C | SER52 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P18031 |
Chain | Residue | Details |
C | CYS216 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
C | SER293 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
C | SER298 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
C | SER304 |