8UH6
Degrader-induced complex between PTPN2 and CRBN-DDB1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 1149 | 128333.8 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | |
| 2 | B (B) | Protein cereblon | polymer | 451 | 51777.0 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 3 | C (C) | Tyrosine-protein phosphatase non-receptor type 2 | polymer | 324 | 37966.0 | 1 | UniProt (P17706) Pfam (PF00102) | Homo sapiens (human) | T-cell protein-tyrosine phosphatase,TCPTP |
| 4 | D (B) | (5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[(4-{1-[(3R)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid | non-polymer | 976.5 | 1 | Chemie (WO8) | |||
| 5 | E (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 1 - 1140 (UniProt: Q16531)
B: 1 - 442 (UniProt: Q96SW2)
C: 1 - 314 (UniProt: P17706)
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -8 | - | initiating methionine |
| Trp -7 | - | expression tag |
| Ser -6 | - | expression tag |
| His -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Ala 0 | - | expression tag |
| His 315 | - | expression tag |
| His 316 | - | expression tag |
| His 317 | - | expression tag |
| His 318 | - | expression tag |
| His 319 | - | expression tag |
| His 320 | - | expression tag |
| His 321 | - | expression tag |
| His 322 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 218076.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1041.9 | |
| All* | Total formula weight | 219118.8 |
