8UH6

Degrader-induced complex between PTPN2 and CRBN-DDB1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA damage-binding protein 1	polymer	1149	128333.8	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB	Homo sapiens (human)
2	B	Protein cereblon	polymer	451	51777.0	1	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) In PDB	Homo sapiens (human)
3	C	Tyrosine-protein phosphatase non-receptor type 2	polymer	324	37966.0	1	UniProt (P17706) Pfam (PF00102) In PDB	Homo sapiens (human)	T-cell protein-tyrosine phosphatase,TCPTP
4	B	(5P)-3-(carboxymethoxy)-4-chloro-5-(3-{[(4S)-1-({3-[(4-{1-[(3R)-2,6-dioxopiperidin-3-yl]-3-methyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl}piperidine-1-carbonyl)amino]phenyl}methanesulfonyl)-2,2-dimethylpiperidin-4-yl]amino}phenyl)thiophene-2-carboxylic acid	non-polymer		976.5	1	Chemie (WO8)
5	B	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 1 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Met -8	-	initiating methionine
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

B: 1 - 442 (UniProt: Q96SW2)

PDB	External Database	Details
Met -8	-	initiating methionine
Trp -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
Pro -4	-	expression tag
Gln -3	-	expression tag
Phe -2	-	expression tag
Glu -1	-	expression tag
Lys 0	-	expression tag

C: 1 - 314 (UniProt: P17706)

PDB	External Database	Details
Met -1	-	expression tag
Ala 0	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	218076.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1041.9
All*	Total formula weight	219118.8

*Water molecules are not included.