8U8J
Co-crystal structure of phosphorylated ERK2 in complex with ERK1/2 inhibitor #16
Summary for 8U8J
Entry DOI | 10.2210/pdb8u8j/pdb |
Related | 8U8K |
Descriptor | Mitogen-activated protein kinase 1, (4M)-4-{(4R)-3-[(2S)-2-methylbutyl][1,2,4]triazolo[4,3-a]pyridin-7-yl}-N-(1-methyl-1H-pyrazol-5-yl)pyrimidin-2-amine (3 entities in total) |
Functional Keywords | protein kinase, atp-competitive inhibitor, conformation selection, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41496.46 |
Authors | Anderson, J.W.,Vigers, G.P. (deposition date: 2023-09-18, release date: 2024-03-27, Last modification date: 2024-04-10) |
Primary citation | Anderson, J.W.,Vaisar, D.,Jones, D.N.,Pegram, L.M.,Vigers, G.P.,Chen, H.,Moffat, J.G.,Ahn, N.G. Conformation selection by ATP-competitive inhibitors and allosteric communication in ERK2. Elife, 12:-, 2024 Cited by PubMed: 38537148DOI: 10.7554/eLife.91507 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report