8U6G
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 3-(2-(2-(3-acryloyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)ethoxy)-4-chlorophenoxy)-5-chlorobenzonitrile (JLJ744), a non-nucleoside inhibitor
Summary for 8U6G
Entry DOI | 10.2210/pdb8u6g/pdb |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 3-chloro-5-{4-chloro-2-[2-(2-oxo-3-propanoyl-2,3-dihydro-1H-benzimidazol-1-yl)ethoxy]phenoxy}benzonitrile, ... (5 entities in total) |
Functional Keywords | reverse transcriptase, antiviral, drug design, hiv-1, viral protein |
Biological source | Human immunodeficiency virus 1 More |
Total number of polymer chains | 2 |
Total formula weight | 114445.54 |
Authors | Prucha, G.,Carter, Z.,Jorgensen, W.L.,Anderson, K.S. (deposition date: 2023-09-13, release date: 2023-11-08) |
Primary citation | Prucha, G.R.,Henry, S.,Hollander, K.,Carter, Z.J.,Spasov, K.A.,Jorgensen, W.L.,Anderson, K.S. Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur.J.Med.Chem., 262:115894-115894, 2023 Cited by PubMed: 37883896DOI: 10.1016/j.ejmech.2023.115894 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
Download full validation report