8U4Q
Structure of REGN7663 Fab-bound CXCR4/Gi complex
Summary for 8U4Q
Entry DOI | 10.2210/pdb8u4q/pdb |
EMDB information | 41888 41889 41890 41891 41892 41893 41894 |
Descriptor | REGN7663 Fab light chain, REGN7663 Fab heavy chain, C-X-C chemokine receptor type 4, ... (7 entities in total) |
Functional Keywords | gpcr, chemokine receptor, antibody, fab, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 209422.62 |
Authors | Saotome, K.,McGoldrick, L.L.,Franklin, M.C. (deposition date: 2023-09-11, release date: 2024-03-13, Last modification date: 2024-10-16) |
Primary citation | Saotome, K.,McGoldrick, L.L.,Ho, J.H.,Ramlall, T.F.,Shah, S.,Moore, M.J.,Kim, J.H.,Leidich, R.,Olson, W.C.,Franklin, M.C. Structural insights into CXCR4 modulation and oligomerization. Nat.Struct.Mol.Biol., 2024 Cited by PubMed: 39313635DOI: 10.1038/s41594-024-01397-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.36 Å) |
Structure validation
Download full validation report