8TYP
Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide
Summary for 8TYP
Entry DOI | 10.2210/pdb8typ/pdb |
Descriptor | Complement C1s subcomponent, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide, ... (4 entities in total) |
Functional Keywords | complement, protease, inhibitor, immune system |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 39037.83 |
Authors | Geisbrecht, B.V. (deposition date: 2023-08-25, release date: 2023-11-29, Last modification date: 2024-02-14) |
Primary citation | Xu, X.,Herdendorf, T.J.,Duan, H.,Rohlik, D.L.,Roy, S.,Zhou, H.,Alkhateeb, H.,Khandelwal, S.,Zhou, Q.,Li, P.,Arepally, G.M.,Walker, J.K.,Garcia, B.L.,Geisbrecht, B.V. Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol., 212:689-701, 2024 Cited by PubMed: 38149922DOI: 10.4049/jimmunol.2300630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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