8TUC
Unphosphorylated CaMKK2 in complex with CC-8977
Summary for 8TUC
Entry DOI | 10.2210/pdb8tuc/pdb |
Descriptor | Calcium/calmodulin-dependent protein kinase kinase 2, (4M)-2-cyclopentyl-4-(7-ethoxyquinazolin-4-yl)benzoic acid, SULFATE ION, ... (5 entities in total) |
Functional Keywords | calcium/calmodulin dependent protein kinase kinase 2, camkk2, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 33998.06 |
Authors | Bernard, S.M.,Shanmugasundaram, V.,D'Agostino, L. (deposition date: 2023-08-16, release date: 2023-12-13, Last modification date: 2023-12-27) |
Primary citation | Chen, Y.,Whitefield, B.,Nevius, E.,Hill, M.,DelRosario, J.,Sinitsyna, N.,Shanmugasundaram, V.,Mukherjee, D.,Shi, L.,Mayne, C.G.,Rousseau, A.M.,Bernard, S.M.,Buenviaje, J.,Khambatta, G.,El Samin, M.,Wallace, M.,Nie, Z.,Sivakumar, P.,Hamann, L.G.,McDonnell, D.P.,D'Agostino, L.A. Identification of Small Molecule Inhibitors and Ligand Directed Degraders of Calcium/Calmodulin Dependent Protein Kinase Kinase 1 and 2 (CaMKK1/2). J.Med.Chem., 66:15750-15760, 2023 Cited by PubMed: 38009718DOI: 10.1021/acs.jmedchem.3c01137 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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