8TRJ

Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP

This is a non-PDB format compatible entry.

Summary for 8TRJ

• Entry DOI: 10.2210/pdb8trj/pdb
• Related: 8TR5 8TR6 8TR7 8TR8 8TRA 8TRB 8TRK
• EMDB information: 41570 41571 41572 41573 41575 41576 41581 41582
• Descriptor: P2X purinoceptor 7, 3'-O-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: membrane protein, ion channel, ligand-gate ion channel, p2x receptor, allosteric antagonist, high-affinity agonist
• Biological source: Rattus; More
• Total number of polymer chains: 3
• Total formula weight: 215122.85

Authors

Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E. (deposition date: 2023-08-09, release date: 2024-08-14, Last modification date: 2024-08-21)

• Primary citation: Oken, A.C.,Lisi, N.E.,Krishnamurthy, I.,McCarthy, A.E.,Godsey, M.H.,Glasfeld, A.,Mansoor, S.E.; High-affinity agonism at the P2X 7 receptor is mediated by three residues outside the orthosteric pocket.; Nat Commun, 15:6662-6662, 2024; PubMed: 39107314; DOI: 10.1038/s41467-024-50771-6

Experimental method

ELECTRON MICROSCOPY (2.78 Å)